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This is the first of a two course pathophysiology and pharmacology series in the BSN curriculum. The course is designed to improve the learner's understanding of how alterations in normal human anatomic structure and physiology function may impact various organ systems, body homeostasis, and medication management. A student-center case-based active learning model will be utilized to exemplify basic and clinical pharmacology principles for common outpatient disease processes. Nursing pharmacology fundamentals, including principles of drug administration, pharmacokinetics, pharmacodynamics, adverse drug effects, drug interactions, and medication errors are introduced. These principles form the foundation for applied pharmacology case studies. Drug class prototypes will be reviewed using an organ system case-based pathophysiologic approach to therapeutics. The case studies illustrate key pathophysiologic and pharmacology concepts thus providing students an opportunity for critical thinking, synthesis, integration, and application of course material to therapeutic decision making, planning, and managing care for individuals.